When a Donor Has a Hidden Mutation: What the TP53 Case Means for Safe, Responsible Sperm Donation
A recent BBC investigation drew international attention to a sperm donor who unknowingly passed on a mutation in the TP53 gene, a key tumor-suppressor gene associated with Li-Fraumeni syndrome, a rare hereditary cancer disorder. The case has raised understandable questions for intended parents, donor-conceived adults, and clinics. But it also highlights why modern screening protocols and adherence …
